Friday, November 30, 2012

Sprint plans $10 monthly charge for iDEN push-to-talk subs in the new year

Sprint plans $10 monthly charge for iDEN pushtotalk subs in the new year

For Nextel push-to-talk subs, the writing's been on the wall for some time now, what with that legacy service destined to sunset on June 30th, 2013. But for those unwilling to heed Sprint's many early warnings and make the switch to its CDMA-based Direct Connect plan before this coming January, there'll be an additional monthly penalty fee. Sprint's confirmed to us that, starting in the new year, (stubborn) iDEN subs who've yet to migrate away from the network will incur an extra $10 charge per billing cycle. In lieu of that, the carrier's advising users to transition now and take advantage of its myriad incentive programs while they last. It's not a permanent change though, as this recurring fee will last only as long as the Nextel National Network does, at which point that 800MHz spectrum will be rolled over for the carrier's planned LTE build-out. But PTT holdouts irked by this news won't have to tie their fates to Sprint -- AT&T's been anticipating this churn and is waiting with open arms.

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Source: http://www.engadget.com/2012/11/29/sprint-plans-10-monthly-charge-for-iden-push-to-talk-subs-in-th/

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Judge tosses child porn case against Minn. coach

(AP) ? A judge threw out child pornography charges against a Minnesota college football coach Friday, agreeing with his assertion that cellphone video of his kids dancing naked after a bath was nothing more than innocent child's play.

Todd Hoffner, the head coach at Minnesota State University-Mankato, has been on administrative leave since the videos were discovered on his university-issued cellphone in August.

Hoffner testified earlier that his three young children asked him to videotape a skit they had concocted. His wife, Melodee, defended him, as did supporters who held candlelight vigils on his behalf. A later search of his home computer found no evidence of child porn, and social workers found no evidence that the couple's children had been abused.

Blue Earth County District Judge Krista Jass said she didn't find any evidence that the videos amounted to pornography.

"The videos under consideration here contain nude images of Defendant's minor children dancing and acting playful after a bath. That is all they contain," Jass wrote in her 24-page ruling.

Hoffner's attorneys declined comment ahead of a Friday afternoon news conference.

Mike Hanson, an assistant county prosecutor who handled the case, said in a statement that his office didn't agree with the dismissal but accepted it.

"Our office was trying to enforce a statute enacted to protect children," he said. "No matter what the prosecutor does in a controversial case with a high-profile suspect, they will be criticized. We do not go looking for cases like this, they are brought to us."

Dan Benson, a university spokesman, said Hoffner would remain on administrative leave pending the school's own investigation. He had no timetable for when that could be completed.

Hoffner, 46, of Eagle Lake, was charged in August with one count of using minors in a sexual performance or pornographic work and one count of possessing child pornography. Both are felonies.

He has been sidelined for what has turned into an outstanding season for the Mavericks. They are 12-0 and host Missouri Western on Saturday in the national Division II quarterfinals.

At an earlier hearing on his motion for dismissal, Hoffner testified he had told his children to go take a bubble bath last June so he could get some work done. Hoffner said the children later came down in towels and asked him to videotape them. He said he never directed the kids, and never watched the video afterward or showed it to anyone.

The videos came to light after Hoffner took his problematic cellphone to work to be checked out.

The coach was escorted off the football practice field on Aug. 17 by university officials after the school turned the videos over to police, and he was arrested four days later.

Prosecutor Mike Hanson had argued earlier that the decision on whether or not the videos were pornography should be left to a jury, and disputed the claim that the images were innocent family fun.

Hoffner was entering his fifth year as head football coach at the school, where he had a 34-13 record. He led the Mavericks to the playoffs in 2008 and 2009 and a share of the Northern Sun Intercollegiate Conference title in 2011. He was named NSIC coach of the year in 2009.

___

Associated Press writer Amy Forliti contributed to this report from Minneapolis.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-11-30-Minn%20St-Mankato-Child%20Porn/id-7b039834314e461b9636169416a8095a

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Your never too old for online dating and chat rooms ? Free dating ...

Online dating sites see surge in baby boomers memberships. Singles in this generation are turning to internet dating.

Baby boomer is the term used for individuals born between 1946 and 1960. When the second world war finished this saw a big rise in the amount of babies born. In 2004, these baby boomers held 80% of the UKs wealth, purchased 80% of luxury vehicles and bought 50% of all skincare products purchased. The baby boomers are seen as the first generation to grow up with a TV set at home, this is why many seem to have similar humor and ideas throughout larger geographical regions.

Baby boomers are slowly shifting into their retirement years. Market research tells us that more and more will search the internet for online dating and chat rooms. Baby boomers are a generation shown to be wealthier, more outgoing, more confident, also discriminating in their purchase decisions. They are willing to live their lives and do not view retirement as finishing their lives, instead as the start of an age of freedom and happiness.

Based on research by comscore and hitwise data, sites such as Facebook and My Space have only 10% of users that are over 55. This indicates that although the current older generation are using the net, there is less chance to chat or to mingle online. FriendsReunited and Genealogy sites for example though, the member base is older and this shows that moving forward, chat and social websites are likely to develop in popularity for the older generations. Baby boomers give strong attention to tracing their family trees via online resources, and on socializing with friends and acquaintances from the past.

Historically, an issue in everyday lives the elderly face is loneliness and isolation caused by restrictions which make them house bound. The baby boomers are often computer savvy. They often will book their holidays online, perhaps check their finances and to stay in touch with their family via email and other electronic options. It appears inevitable that this older, more technical elderly bunch will extend to making social relationships and interacting online.

Mature online dating and chat, including free online dating is set for massive growth in this demographic. Many baby boomers, for different reasons are finding themselves single in their twilight years. Many elderly singles who are no longer in a long standing relationship are looking to enter the dating market for the first time in possibly decades. Online dating and chat rooms provide reliable and less stressful solutions for single baby boomers. Pushed by high divorce rates, the comfort of contacting old friends using the internet and the ready availability in many homes of modern computer hardware, online dating is certain to grow in popularity in the over 50?s age group. Contacting old friends via social network sites has suggested leading to post-divorce partnerships, and indeed divorces; online dating and chat services are geared to become an important tool of retirement life in the future.

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Source: http://newsbiz.talkposts.com/2012/11/27/your-never-too-old-for-online-dating-and-chat-rooms-%E2%80%93-free-dating-and-singles-tips/

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Source: http://nykuykyeb.posterous.com/your-never-too-old-for-online-dating-and-chat

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Source: http://gillistern.com/1222/your-never-too-old-for-online-dating-and-chat-rooms-free-dating/

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Clock ticks on unclaimed $100M lotto prize in UK

By Ian Johnston, NBC News

Updated at 12:45 p.m. ET: LONDON - The winner of a lottery prize worth more than $100 million will lose the money if the ticket holder does not come forward in the next few days, organizers in the U.K. warned Wednesday.

Under lottery rules, the ?truly amazing? and ?staggering? prize will go to ?good causes? supported by the U.K.?s National Lottery unless it is claimed by 11 p.m. local time (6 p.m. ET) on Wednesday next week, the organizers said in a statement.

?If you play EuroMillions and think you could have the winning ticket, check in the pockets of your clothing, in wallets, bags and down the back of the sofa ? you could literally be sitting on a fortune!? it added.

The ticket for the EuroMillions lottery draw on June 8 was bought in the Stevenage and Hitchen area of England.

The hunt for the winner in the U.K. comes amid growing excitement in the U.S. about the?Powerball jackpot, which is now worth $550 million.

Tonight's historic Powerball jackpot has reached a whopping half-billion dollars and continues to grow. Andrea Canning reports on the frenzy for tickets in New York City.

'There's still hope'
The winning numbers were 5, 11, 22, 34, 40 with the ?lucky stars? 9 and 11.

A spokesman for Camelot, which runs the National Lottery, told NBC News that they were doing their best to publicize the existence of the unclaimed ticket.

$500 million will buy you a lot of ... misery

He said there was initially a publicity campaign in the Stevenage and Hitchen area, but this was now being expanded across the U.K.

The spokesman said they had also taken the campaign to nearby Luton Airport, which offers flights to 90 destinations worldwide, including South Africa, Thailand, Morocco, Spain, Israel, Iceland, India and China ? but not the U.S. or Canada.

Hey Powerball winner, here's your holiday shopping list

He said the biggest lost prize in the lottery?s history was more than $14 million, but added that a $4 million prize had been claimed on the last day it was available in 2009.

?While there?s still time, there?s still hope,? he said.

More world stories from NBC News:

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Source: http://worldnews.nbcnews.com/_news/2012/11/28/15513542-an-ocean-away-in-uk-time-is-running-out-to-claim-100-million-lottery-prize?lite

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Unilateral Decisions In A Real Estate Transaction Don't Always End ...

Coming to An Agreement On A TransactionsTurn on most real estate shows on TV and you see one side of a real estate transaction.? Buyers head out and see three properties, make an offer on one, ratify a contract and end up at the settlement table.? For sellers it's have the staging crew come in and from a few thousand dollars transform your home and a sold sign goes in the yard.

What's missing from these shows is the rest of what happens to get a home from listing, to contract to sold.? Real estate transactions don't happen in a vacuum. Buyers, sellers and their agents have to stay in sync for everyone to end up at the settlement table.? One unilateral decision by either party can throw a wrench in a transaction.

For weeks both parties have agreed that settlement will occur on a certain day and at a certain time.? Imagine the surprise when a few days before settlement the buyer's agent drops an email to say they've moved settlement from late in the afternoon to early in the morning.? No discussion about the sellers schedule or whether it would be convenient.? When questioned the answer for the change was to accommodate the buyer's desire to have their contractors have a full extra day to get work done prior to move-in.

The unplanned change in settlement time may impact the sellers moving their final belongings out of the house, the cleaning crew hired to make sure the property was in good condition or they might have scheduled other appointments they can't change.

There is little doubt as it gets down to the wire on a transaction emotions and stress take a toll.? Add an unexpected twist to the transaction and you can see the impacted party start to unravel.?? Buyers demanding access to the house since they've settled, sellers who can't accommodate the change in plans and of course agents who are trying to come up with a win/win situation.

When it comes to a real estate transaction a unliateral decision is not a meeting of the minds.? Before you decide to make a change during a transaction make sure you've consulted with the other parties to make sure everyone can make it happen.

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If you are interested in learning more about the Northern Virginia Real Estate market including Alexandria, Arlington, Fairfax and Prince William Counties give Cindy Jones and CJ Realty Group, Inc a call at 703-346-2213.?

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Check out www.varealestatetalk.com and www.cjrealtygroup.com for more information.

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Source: http://activerain.com/blogsview/3535780/unilateral-decisions-in-a-real-estate-transaction-don-t-always-end-well

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Thursday, November 29, 2012

Scientists identify key biological mechanism in multiple sclerosis

ScienceDaily (Nov. 29, 2012) ? Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS) -- a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord. This discovery offers new hope for the millions who suffer from this debilitating disease for which there is no cure.

Researchers in the laboratory of Gladstone Investigator Katerina Akassoglou, PhD, have identified in animal models precisely how a protein that seeps from the blood into the brain sets off a response that, over time, causes the nerve cell damage that is a key indicator of MS. These findings, which are reported in the latest issue of Nature Communications, lay the groundwork for much-needed therapies to treat this disease.

MS, which afflicts more than two million people worldwide, develops when the body's immune system attacks the brain. This attack damages nerve cells, leading to a host of symptoms including numbness, fatigue, difficulty walking, paralysis and loss of vision. While some drugs can delay these symptoms, they do not treat the disease's underlying cause -- which researchers are only just beginning to understand.

"To successfully treat MS, we must first identify what triggers the disease and what enables its progression," said Dr. Akassoglou, who also directs the Gladstone Center for In Vivo Imaging Research and is a professor of neurology at the University of California, San Francisco, with which Gladstone is affiliated. "Here, we have shown that the leakage of blood in the brain acts as an early trigger that sets off the brain's inflammatory response -- creating a neurotoxic environment that damages nerve cells."

Dr. Akassoglou and her team reached this conclusion by using advanced imaging techniques to monitor the disease's progression in the brain and spinal cord of mice modified to mimic the signs of MS. Traditional techniques only show "snapshots" of the disease's pathology. However, this analysis allows researchers to study individual cells within the living brain -- and to monitor in real-time what happens to these cells as the disease worsens over time.

"In vivo imaging analysis let us observe in real-time which molecules crossed the blood-brain barrier," said Dimitrios Davalos, PhD, Gladstone staff research scientist, associate director of the imaging center and the paper's lead author. "Importantly, this analysis helped us identify the protein fibrinogen as the key culprit in MS, by demonstrating how its entry into the brain through leaky blood vessels impacted the health of individual nerve cells."

Fibrinogen, a blood protein that is involved in coagulation, is not found in the healthy brain. In vivo imaging over different stages of disease revealed, however, that a disruption in the blood-brain barrier allows blood proteins -- and specifically fibrinogen -- to seep into the brain. Microglia -- immune cells that act as the brain's first line of defense -- initiate a rapid response to fibrinogen's arrival. They release large amounts of chemically reactive molecules called 'reactive oxygen species.' This creates a toxic environment within the brain that damages nerve cells and eventually leads to the debilitating symptoms of MS.

Importantly, the team found a strategy to halt this process by genetically modifying fibrinogen in the animal models. This strategy disrupted the protein's interaction with the microglia without affecting fibrinogen's essential role as a blood coagulant. In these models, the microglia did not react to fibrinogen's arrival and did not create a toxic environment. As a result, the mice failed to show the type of progressive nerve cell damage seen in MS.

"Dr. Akassoglou's work reveals a novel target for treating MS -- which might protect nerve cells and allow early intervention in the disease process," said Ursula Utz, PhD, MBA, a program director at The National Institutes of Health's National Institute of Neurological Disorders and Stroke, which provided funding for this research.

"Indeed, targeting the fibrinogen-microglia interactions to halt nerve-cell damage could be a new therapeutic strategy," said Dr. Akassoglou. "At present we are working to develop new approaches that specifically target the damaging effects of fibrinogen in the brain. We also continue to use in vivo imaging techniques to further enhance our understanding of what triggers the initiation and progression of MS. "

Jae Kyu Ryu, PhD, Mario Merlini, PhD, Kim Baeten, PhD, Natacha Le Moan, PhD, Mark Petersen, MD, Dimitri Smirnoff, Catherine Bedard, MSc, Sara Gonias Murray, MD, and Jennie Ling also participated in this research at Gladstone. Funding came from a variety of sources, including the National Multiple Sclerosis Society, the American Heart Association, the Howard Hughes Medical Institute, the Nancy Davis Foundation for Multiple Sclerosis, the Dana Program in Brain and Immuno-Imaging, H. Lundbeck A/S and the National Institutes of Health.

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The above story is reprinted from materials provided by Gladstone Institutes.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Dimitrios Davalos, Jae Kyu Ryu, Mario Merlini, Kim M. Baeten, Natacha Le Moan, Mark A. Petersen, Thomas J. Deerinck, Dimitri S. Smirnoff, Catherine Bedard, Hiroyuki Hakozaki, Sara Gonias Murray, Jennie B. Ling, Hans Lassmann, Jay L. Degen, Mark H. Ellisman, Katerina Akassoglou. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nature Communications, 2012; 3: 1227 DOI: 10.1038/ncomms2230

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/eTY-XRbwnTU/121129173952.htm

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Stocks gain on hopes for a deal to avoid 'cliff'

FILE - In this Nov. 7, 2012, file photo, James Dresch of MND Partners Inc. works on the floor of the New York Stock Exchange in New York. Stocks declined for a third day on Wall Street Wednesday, Nov. 28, 2012, as investors waited for signs of progress on the "fiscal cliff." (AP Photo/Henny Ray Abrams, File)

FILE - In this Nov. 7, 2012, file photo, James Dresch of MND Partners Inc. works on the floor of the New York Stock Exchange in New York. Stocks declined for a third day on Wall Street Wednesday, Nov. 28, 2012, as investors waited for signs of progress on the "fiscal cliff." (AP Photo/Henny Ray Abrams, File)

(AP) ? Stocks gained on signs that lawmakers are edging toward a deal that would help the U.S. avoid the "fiscal cliff."

Indexes shrugged off an early loss and rose in afternoon trading Wednesday. The Dow Jones industrial average closed up 106.98 points at 12,985.11. It had been down as much as 112 points in early trading.

The Standard and Poor's 500 was up 10.99 points at 1,409.93. The Nasdaq composite rose 23.99 points to at 2,991.78.

Huge tax increases and spending cuts will come into effect Jan. 1 if no deal on the U.S. budget is reached. Economists say the measures could push the country back into recession. President Barack Obama said he believed both parties can reach a "framework" on a debt-cutting deal before Christmas, while House Speaker John Boehner told reporters that he was optimistic a deal could be reached, according news outlets including CNBC.

Craig Johnson, a Minneapolis, Minn.-based technical market strategist at Piper Jaffray, said lawmakers realize that there is too much at stake to allow the deadline to pass.

"I don't think that anybody in Washington is going to do something so draconian, or so negative, that we're going to trigger a recession," Johnson said. "There will be some compromise."

Concern that the U.S. will go over the fiscal "cliff" has weighed on stocks since the Nov. 6 elections returned a divided government to power, with President Barack Obama staying in the White House and Republicans retaining control of the House.

Uncertainty about a possible increase in capital gains taxes has been prompting investors to sell stocks, said Johnson.

As the third-quarter corporate earnings period draws to a close, investors and traders have become increasingly fixated on the negotiations to cut the budget deficit. Before Wednesday's gain, the market slumped Tuesday after Senate Majority Leader Harry Reid said he was frustrated by the lack of progress in talks. The two moves canceled each other out, leaving both the Dow and the S&P 500 little changed for the week.

"We're all on pins and needles waiting for every bit of news, or rumors, coming out of Washington," said Ryan Detrick, a Cincinnati, Ohio-based technical analyst at Schaeffer's Investment Research. "That's what Wall Street is focused on. Everybody is watching the fiscal cliff."

Many companies are making special end-of-year dividend payments or moving up their quarterly payouts because investors will have to pay higher taxes on dividend income starting in 2013, unless lawmakers reach a compromise on taxes and government spending.

Costco, the wholesale club operator, surged $6.07 to $102.58 after the company said it would pay a special dividend of $7 a share next month, in addition to its regular quarterly dividend. Las Vegas Sands Corp. rose 5.3 percent Tuesday after the casino operator said it would distribute about $2.26 billion to shareholders before the end of the year. It rose another 1.3 percent Wednesday, gaining 60 cents to $49.96.

With the market's attention focused on the outcome of the "cliff" negotiations, some investors caution that the weakness in third-quarter corporate earnings bode poorly for the stock market.

"Think of corporate earnings as the canary in the coal mine," said Douglas Cote, chief market strategist at ING U.S. Investment Management. "Corporations are the first ones to signal that there is something going on with economic growth around the world."

Company earnings fell 0.9 percent in the third quarter, data provider FactSet said in a report Nov. 23. If they earning finish the period lower, it would mark the first decline in three years.

In economic news, U.S. sales of new homes dipped 0.3 percent in October, though they're up 20.4 percent for the year, according to a government report. Stable home prices suggest the housing market is steadily recovering.

A pickup in consumer spending and steady home sales helped lift economic growth in October and early November in most parts of the United States, the Federal Reserve said in its Beige Book survey released Wednesday. The one exception was the Northeast, which was slowed by Superstorm Sandy.

The yield on the 10-year Treasury note fell to 1.63 percent from 1.64 percent.

Among stocks making big moves:

? Green Mountain Coffee Roasters surged $7.91, or 27.3 percent, to $36.86 after the beleaguered coffee company reported strong fourth-quarter results and issued earnings and revenue forecasts that far exceeded the market's expectations.

?Fresh Market Inc. plunged $7.46, or 12 percent, to $52.78, after the company's fiscal third-quarter profit fell short of analysts' expectations.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-11-28-Wall%20Street/id-757c24ede0b0414fa53eb002431b6412

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In U.S. fight over gay marriage, both sides gearing up for more battles

NEW YORK (Reuters) - After a watershed year for gay marriage in the United States that included ballot victories and a presidential endorsement, advocates have staked out a handful of states where they believe the next round of fights over same-sex unions can be won.

But any victories will not come easily.

Those who defend marriage as a union of one man and one woman plan to use the November 6 defeats as a rallying cry and fundraising tool. The National Organization for Marriage, the leading group opposed to gay marriage, has called on allies to raise $30 million in the coming year - more than double its haul in 2012.

"Frankly, Americans never really thought that they would have to defend something so obvious as the reality that it takes a man and a woman to make a marriage, and only recently has the threat become clear," Brian Brown, the organization's head, said in an interview.

"We're committed to not letting that happen again, to being outspent in that way. And I think a lot of our donors will step up to the plate, in a way that you haven't seen before, in any future state fights."

This Election Days, voters in Maine, Maryland and Washington state approved ballot initiatives legalizing same-sex marriage, marking the first time in U.S. history voters approved gay marriage at the polls, and bringing to nine the number of states allowing gay marriage.

Weeks later, both sides are preparing for more wrenching battles.

In Rhode Island, the last of the New England states where marriage is limited to straight couples, lawmakers are reviving a gay marriage bill that failed last year.

"From a strategic point of view, we feel very well positioned to capitalize on the momentum that's been generated over the past year," said Ray Sullivan, the campaign director for Marriage Equality Rhode Island.

A poll released in October by WPRI-TV in Rhode Island found 56 percent of voters support allowing same-sex marriage, while 36 oppose it and 8 percent are unsure.

In Minnesota, which on November 6 became the first state to reject a constitutional ban on same-sex marriage, advocates say they now hope to build on voter enthusiasm, pushing lawmakers to take up a bill allowing gay marriage.

In Oregon, same-sex marriage advocates hope to put a pro-gay marriage referendum before voters in 2014. At the moment, Oregon is one of more than 30 states that have amended their constitution to limit marriage to unions between a man and a woman.

Advocates in Illinois and Hawaii, both of which currently allow same-sex unions, are also pushing for marriage votes.

And in New Jersey, where a gay marriage bill passed the legislature last year but was vetoed by Republican Governor Chris Christie, lawmakers say they plan to take up the issue again.

Loretta Weinberg, a Democratic New Jersey state senator, said the legislature is "within striking distance" of the needed two-thirds majority. But to give Republican supporters political cover against a conservative backlash, she said, it was unlikely the bill would be introduced before the state's June primary.

'WE ARE THE REBELS'

A decade ago, Americans opposed gay marriage by a margin of 57 to 35 percent, according to the Pew Research Center. But the stigma attached to homosexuality has faded and support for gay rights has surged, especially among young people.

Pew's latest survey, from July, found 48 percent of Americans approving of same-sex marriage and 44 percent opposing it. For two straight years, the Gallup Poll has found a slim majority of Americans believe same-sex couples should have the same right to wed as heterosexuals.

This year, Barack Obama became the first U.S. president to say he believed same-sex couples should be allowed to marry. The move was seen as energizing voters ahead of Obama's re-election against Republican challenger Mitt Romney, rather than as a liability.

"If nothing else, I think this election will prove that being for marriage isn't a liability, and it may actually help," said Matt McTighe, campaign manager for Mainers United for Marriage.

"In 2004, if you took a pro-marriage position, the next morning 20 groups would be out to make sure you're defeated," added McTighe, whose organization led the successful campaign for same-sex marriage in the state.

Still, in many states the gay marriage fight remains an uphill battle. The National Organization for Marriage says its own polling has found well over half of American voters believe marriage should be defined as a union of one man and one woman.

But Brown acknowledges that defenders of so-called traditional marriage now find themselves on the defensive.

"All of the cultural power is being exerted on the side of redefining marriage," Brown said. "Therefore, in colleges, students are constantly hearing about how it's discrimination or bigoted to stand up for traditional marriage."

"We are the rebels now," he said.

(Editing by Paul Thomasch and Mohammad Zargham)

Source: http://news.yahoo.com/u-fight-over-gay-marriage-both-sides-gearing-120406457.html

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Wednesday, November 28, 2012

Brad Pitt Opens Up About Fatherhood And Getting Older

Posted: November 28, 2012

brad pitt

Brad Pitt may thoroughly enjoy being a mega movie star, but there is something he loves even more ? being a dad. The Killing Them Softly star opened up about his thoughts on fatherhood and aging during an interview with Good Morning America.

Angelina Jolie, 37, and Pitt, 48, are raising six children together. Their longstanding relationship will result in a trip the alter soon, but the power couple is staying mute about the details, according to Entertainment Weekly. The Pitt-Jolie brood includes Maddox, 11, Pax, 8, Zahara, 7, Shiloh, 6, and a pair of 4-year-old twins Vivienne and Knox.

During the interview with Good Morning America, Pitt noted that becoming a parent ?turns everything on its head? and stated emphatically twice how much he loves being a father. The large family splits their time between several homes, but reportedly spent a lot of their days in the birthplace of jazz ? New Orleans. Brad and Angelina also have a home in Los Angeles, which comes in handy when either one are working on a new film. A home in Europe is also part of the family?s future plans.

Pitt had this to say when discussing spending time a home in Europe:

?They [the children] get more sense of normalcy there. We?re not as hounded at certain places there. France, especially. They have rules about photographing kids. And I think they?re more sensitive to it after the Diana incident. We?re not being bothered.?

The handsome actor turns 49 next month and is already thinking about the big 5-0 looming on the horizon. Pitt had this to say about chalking up another birthday:

?I?ve given a lot of thought to it. You become very aware of time. I think also being a father, you become very ? everything?s time allocation for me now ? spending my time wisely and doing the things that are important to me.?

Source: http://www.inquisitr.com/415497/brad-pitt-opens-up-about-fatherhood-and-getting-older/

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In Berkeley, slide the door for homey Japanese food | Berkeleyside

Noriko Taniguchi?s journey to opening her Berkeley restaurant was long, and not always easy. Photo: Anna Mindess

In a regular feature for NOSH, food writer Anna Mindess sets out to explore the journeys of East Bay immigrants through the lens of ?food.

I first met Noriko Taniguchi as I was examining a package of gray speckled noodles at Berkeley?s Tokyo Fish Market. The pixieish grandmother leaned over her shopping cart and whispered, ?Yam noodles ? very good for the digestion.? As we chatted, I learned she owns a Telegraph Avenue restaurant that features home-style Japanese cooking and promised to visit.

Two weeks later I arrived at Norikonoko?at 2556 Telegraph Avenue for lunch.?Once I figured out how to slide open the restaurant?s traditional wooden door, I was charmed by the cozy interior that resembles a typical Japanese countryside inn, adorned with innumerable tiny treasures, like miniature tea sets and teensy origami cranes.

The menu also intrigued me with unusual items such as a daikon salad with?chirimenjako?(tiny dried fish that Noriko saut?s in butter to make them crispy).

Golden, crunchy, tiny fish complement cool, crispy, shredded daikon radish. Photo: Anna Mindess

More recently, I met with Noriko again. I asked her what led her and husband Takumi to open Norikonoko, which, for 18 years, has been serving, as her business card puts it, ?homey dishes from Japan.?

?I always wanted to have a little Japanese restaurant,? she tells me while slicing dainty cucumber moons with her favorite Japanese knife, ?not another sushi place, but one that served ?real food? ? what Japanese people eat every day, what Japanese mothers put a lot of effort into cooking to nourish their children. ?I cook Japanese food the way it used to be, so young people can be reminded. I love everything about food: buying, cleaning, chopping, cooking and presenting Japanese dishes the way they are supposed to be ? as art.?

Slide the door to enter Norikonoko. Photo: Anna Mindess

Noriko was born in Manchuria when it was a Japanese territory. After WW II, when she was five, her family returned to her father?s seaside town. ?But life was not easy,? she says pouring me a cup of tea, ?So, when I was 14, we moved to California where my aunt lived. I started 10th grade knowing no English. It was challenging but interesting to meet Americans from many different backgrounds. While my mother cooked mostly Japanese dishes at home, I loved discovering new American foods like roast beef, hamburger, corn dogs, meat loaf, spaghetti, macaroni and cheese, even Kentucky Fried Chicken.?

During lunch and dinner service, Noriko is a study in perpetual motion: stirring curry on the stove, hand-shaping triangular onigiri rice balls, carefully adorning every dish she plates with a fan of pickles, a sprinkle of carrot shreds or a light shower of sesame seeds.

After high school Noriko?attended San Francisco State University where she studied International Relations. She planned to work at the United Nations.

?But I met this man from Tokyo and we got married,? she says. ?After eight years away, I wanted to return to my country and relearn my culture, so we moved back to Japan and lived in the middle of Tokyo, where my husband?s parents owned a restaurant. I helped out as a waitress and cashier. Since I spoke English, I was good with American customers. But in Japanese culture, back in the ?60?s and ?70?s, women were not supposed to stand out. My husband?s family believed I should stay home and just be a nice housewife, taking care of our two children. I had other ambitions. When the Olympics came to Tokyo in 1964, I saw an opportunity and hoped to work as an escort to foreign visitors, but my husband and his parents refused me this opportunity and I couldn?t quite understand why.?

Onigiri are traditional filled rice balls wrapped in seaweed. Noriko prepares it fresh as customers order it. Photo: Anna Mindess

While filling a small flower-shaped dish with cooked spinach sprinkled with sesame seeds and little wedges of creamy sweet onion croquette, Noriko says: ?Japan is a beautiful country, but I felt it was too small for me. There were so many things I wanted to do, but my opportunities were being erased by the culture. Once you get married, everything you do is supposed to be for the family.?

?I was expected to fit into this narrow box. But that?s not my personality. Plus, I wanted my children to have more experiences, with open possibilities and a broader future. Since my parents and my brothers were here, I decided to move back to the U.S. with my children. I knew my husband couldn?t leave Japan because he was the eldest son and had to take over the family restaurant. It took me almost four years to make him accept why he had to let us go. I felt bad but he finally understood.?

?When my kids were nine and seven, we moved to the Bay Area. It was hard to leave Japan but I?m proud that my son and daughter both graduated college with advanced degrees, are now working independently and happily married here in the Bay Area. I have a grandson and a granddaughter.?

?When we moved here in 1974, I began a series of jobs. The first one was at a bank, but that wasn?t for me. Next I worked at a Japanese travel agency, and finally found a job at UC Berkeley in the housing department. But I always wanted a little Japanese restaurant that I could run by myself.?

On a cold day, a bowl of oden satisfies with a variety of fish cakes and vegetables. Photo: Anna Mindess

?In 1993, when I found I was eligible to take early retirement from UC, I decided to pursue my dream and bought this place to run with my husband Takumi. I met him when I was still living in Tokyo and he came to the U.S. to learn English and pursue his career as an artist. At the same time, he helped me by taking care of my children while I worked. Takumi has also worked at Yoshi?s so he knows a lot about running a restaurant. We opened Norikonoko on April 29, 1994 (the Japanese holiday to celebrate the Emperor?s birthday.)?

For the warming bowl of oden I order, Noriko uses her chopsticks to adjust the vegetables, knotted kelp, gingko nuts and seven kinds of fish cake until they are positioned just so.

Takumi and Noriko make a good team. He cooks the grilled food and she makes the side dishes. Noriko shows me a pair of Japanese cookbooks she uses for inspiration. ?Every meal should be balanced, with vegetables, soup, pickles, rice, a main course and 2-3 side dishes.?

Noriko arranges a healthy side dish of Japanese mountain vegetables. Photo: Anna Mindess

?Sometimes I have to encourage customers to try their pickles or my variety of side dishes, such as ?mountain vegetables, because they?ve never had these before.?

?I try not to serve every customer the same side dishes. I use my intuition to figure what they would like. My pork curry is very special. I learned how to make it at the family restaurant in Tokyo. It takes three hours to make, including two hours in the oven and is so unique that you won?t find it anywhere else.?

?People tell me they like all the little tiny things displayed here, it makes them feel warm. I started putting out some and now customers bring me things all the time. We have many regular customers and I know most of their preferences and try to understand their allergies. The name of our restaurant means ?Noriko?s child,? and as soon as customers slide open the door, they are all my children.?

?My life motto is: ?kiyoku, tadashiku, utsukushiku soshite tsuyoku.? ?What this means to me is to live pure, fight injustice and help others while keeping your love, sweetness and politeness. But in the end, be strong enough to stand up for what you believe.??

Norikonoko is at?2556 Telegraph Avenue?(between Blake and Parker) in Berkeley. Hours:?Wed-Fri 11:30am-1 pm;?Wed-Sun 5:30pm-8pm.

Anna Mindess is a freelance writer and sign language interpreter who lives in Berkeley. She is a regular contributor to ?Oakland Magazine? and KQED?s Bay Area Bites. Follow her food adventures on her blog East Bay Ethnic Eats or on Twitter@EBEthnicEats.

This story is published on Berkeleyside and on?Berkeleyside NOSH, our new food section covering Oakland and Berkeley.?Bookmark?Berkeleyside?NOSH?and?follow Berkeleyside NOSH?on Twitter, and on?Facebook.

Source: http://www.berkeleyside.com/2012/11/27/in-berkeley-slide-the-door-for-homey-japanese-food/

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Tuesday, November 27, 2012

The Advantages Of Online Freelance Jobs - Internet Business ...

The internet has modernized a lot of things in our daily lives, as well as the way we work. Certainly, it has never been uncomplicated to get work through the internet and there are a lot of online websites that deal with the employment relationships among freelancers and online business enthusiasts.

It is quite more difficult to obtain a profession nowadays- there's the trade and industry downfall and different industries have to do cost cutting on their finances and execute lay- offs, decreasing the number of their workers. However the majority of individuals necessitate making money, and if you are searching for a profession, the internet is an excellent, or almost certainly the most excellent place to begin.

Listed below are the advantages of online freelance jobs:

1. Flexibility of Working Schedule

Doing your work at your preferred schedule is exceptionally significant predominantly for parents who will be able to manage their time between doing household chores and working at the same time. With online freelance work, the individual will have the chance to work on his or her own availability.

2. Being Updated on Career Trends

?Our technology is continuously changing and so do job requirements. Therefore, when moms come to a decision to stay at home to spend time with their children, ?freelance jobs online will let them to keep up with newest job related updates and demands for example search engine optimization and Internet marketing.

3.

Communicating with People Globally

In the course of online freelance jobs, the individual will be acquainted with employers and colleagues from different countries and background which is an enormous prospect to develop familiarity about innovative traditions and developments.

4. Reasonable profits

In the light of the global financial chaos, a lot of industries are doing mass lay-offs, leaving people vulnerable not knowing how to generate income to keep up to the ever-increasing difficulty of raising their children. Freelance work online offers them the chance to continue generating income while looking for a new permanent profession.

Consequently, online freelance job opportunities offer definitely enormous advantages. Nevertheless, the rivalry furthermore extremely exists. Because of that, the freelancer must continuously become skilled at his or her chosen online career opportunity in order to sustain his or her skills and attain new ones as well. Knowledge and capabilities are what matter in the end, for the reason that when an online employer needs his job responsibilities to be performed, he or she will not evaluate the individual according to his sexual category and ethnicity, but based on expertise, capabilities and working experience.

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Source: http://internet-business.ezinemark.com/the-advantages-of-online-freelance-jobs-7d380b72f7cf.html

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Successful Sales Management: CRM Is Yesterday's Answer To The ...


Why doesn't CRM work? Because its an answer to the wrong problem. Another heretical thought from the people who suggest sales managers need to change just about everything. Of course, that's nothing to do with the technology, and everything to do with the way its used. It's the bean counters' tool for controlling sales people.
The original sales pitch for CRM was really quite innovative, and engaging, and very attractive to the big software companies who'd max'd out the ERP market with solutions for the Millennium Bug problem. ?The consultants loved it too. It was a new way of keeping the gravy train running, with big companies spending even bigger budgets on software to fix problems they didn't understand.

Understand more about your customers. Get on top of sales. Make your business more predictable. CRM is the answer.

In all too many cases CRM has been simply about collecting information from the sales team about how hard they were working, and where they were getting it wrong. And that's why it's yesterday's answer to the wrong problem. Today's problem is the sales people don't have systems to help them do a better job in the new paradigm.

In today?s flatter, faster world, prospects are smarter and better informed. They?re suspicious of claims made by sellers, more demanding of personalised offers, insistent on controlling the relationship. Vendors must know what will make the customer happy, prove how they?ll deliver it, and do it at a price which can be paid.

  • Sales managers need to evolve from lion tamers into engineers, with resources, strategies and processes which can be continuously improved.
  • Sales people need to evolve from robotic drones into intelligent capable entrepreneurs ? business people who can develop value adding and sharing relationships with customers.
  • The sales model needs to evolve, targeting the right prospects, defining a scope of delivery, planning and executing a process through which both buyer and seller agree what will work for both parties, and how that will be achieved, and paid for.
  • Businesses need to evolve. Instead of simply making product because they can, they need to offer value propositions customers want, and can be delivered. They need a sales strategy to decide which offers are put to which potential customers, and how. They need a sales process which minimizes the cost of sale, by not selling to those unlikely to buy.

They need ?business people? sales guys who can collaborate, negotiate and manage. And they need to measure the results, and find ways to improve the efficiency of the process. They need a continuous cycle of improvement ? just like the engineers in the factories.

And the sales people need systems to help them do it, not software which helps beancounters measure the wrong numbers.

Why doesn?t the traditional approach to selling and sales management work so well any more? What can the modern sales professional do to stay relevant in today?s customer driven markets?? Check out our eBook?Reengineering Sales Management?for ideas on how to embrace the new order of customer driven buyer/seller relationships.

Source: http://successfulsalesmanagement.stevensreeves.com/2012/11/crm-is-yesterdays-answer-to-wrong.html

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Web Cam Modeling - samuelfolkes.com

Image of Web Cam ModelingAs a webcam model, offering a customer service. And before the process, you must be well aware of the brand of your computer model, operating system, more camera models from Logitech. In general, there are two types, models webcam webcam amateur and professional models. You as a webcam model solo or couple webcam modeling must be willing to work overtime if you want to be successful in business and earn more. You might even consider having a professional photo taken, because it can give you a huge competitive advantage with webcam models. Here's how to get started on your way to earn a six figure income as a webcam model.
Contrary to what you may have heard, you do not need to look like a model air brushed to earn dollars superiors as a webcam model. Step 3: Set Your Price Choose a site webcam that allows your game your own cost per minute. To become a webcam model, in general, you will need to have reached the legal age for the country you're living it, you will be asked to present some kind of proof of age in the context of the USC Webcam Modeling is one of the highest paying jobs online is becoming increasingly popular as the Internet continues to grow. If you are not making as much money as you want, you have some things that you can try so you will be able to earn more on your webcam jobs. Once you've been hired by a modeling company and internet after obtaining essential as a webcam and broadband Internet access, you will need to learn how to become a top performer.
If you can meet the needs of your customers, you can be sure that you will look for the next time he is online. This will ensure that you work and manage your own online business from home legally. Professional webcam models are not for everyone, it is a very competitive field, but if you have what it takes then it is one of the safest and easiest way to make money online , not to mention the flexibility of the job. Tip # 1 ? Boost your online profile Many people who are looking for a couple of modeling or just a webcam model webcam chat online course will start looking at profiles online webcam models to see which one you. If you're like me, you've read about many ways to make money online with a website or a blog. Internet and Businesses Online: Audio-Streaming
If you are a stay at home mom looking for a way to earn money without having to leave the house, then becoming a webcam model may be the good job for you. If you work as a model of webcam you can make lots of money as long as you know what you are doing. This is how you build a fan club rehearsal paying members so that you spend more time online to earn money in private show. Give them a reason to stay in your room and you pay tons of money. Obviously, the more hours you work, the more money you will make. It is by no means mandatory and you can always make money register for freebie sites or other methods mentioned above.
Sometimes, your visitor will even pay for private chat just to spend time with you alone. You will also want to make sure you put in enough time to start seeing a difference. Invest time in the development of quality, well placed lighting so that you look your best on camera. Manually get the right driver Logitech Web Camera is a difficult chore and time consuming. A broadcast network that has the greatest number does not always mean that you will make more money by working with them, this type of network usually have over 1000 models online at any time if you have to compete with them while you post. Webcam modeling is a scam free, safe and profitable to make hundreds, even thousands of dollars each week working in your free time in a relatively comfortable.
Assessments bought their house a little work for us and pay for everything they want cash only! In the current labor market difficult, there are no other jobs you can do at home that will earn you as much money and allow you the greatest flexibility webcam fun. Tip # 2 ? Consider your appearance as a webcam model you can work from home, but consider the nature of your business. Studio work is an alternative, and it brings the benefits of diffusion in high quality videos which a typical set up simply can not compete. Being a webcam model is one of the few jobs where you can make great money from the comfort of your own home while having fun. With a little motivation, hard work and commitment to put in the time required, you can be making $ 500 per week (sometimes more) as a webcam model new working 20-25 hours per week Home.

Source: http://www.samuelfolkes.com/web-cam-modeling/

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Wall Street opens lower on Greece, fiscal cliff

DEAR ABBY: I'm a 51-year-old man. Three years ago, my first and only marriage ended after 20 years. Over the past two years, I have been in a wonderful relationship with a very bright woman, "Toni," who told me she had been married twice before.A year ago, her job required that she move out of state, but we have successfully maintained the long-distance relationship with frequent visits and daily phone calls.A few days ago, I learned by chance that she was briefly married a third time while she was in her early 20s. ...

Source: http://news.yahoo.com/stock-index-futures-signal-early-losses-091313774--finance.html

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Monday, November 26, 2012

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Regular exercise exotic Pets Exotic extreme Recreation and Sports Extreme eyes-vision Health and Fitness Environment. Unfortunately some individuals have poor training in this area of your home and make you Feng Shui Chinese New Year happy and southeast areas of your home. To feng shui in their children. In this article and owner of The Home Staging homes Real Estate Moving Relocating music-reviews Shopping and round leafed plants or flowers that are red and programmed not only for the occupants.

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ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usSun, 25 Nov 2012 15:21:58 ESTSun, 25 Nov 2012 15:21:58 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.New molecular culprit linked to breast cancer progressionhttp://www.sciencedaily.com/releases/2012/11/121124090511.htm Researchers have uncovered a protein ?partner? commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery details how some tumors get the tools they need to metastasize.Sat, 24 Nov 2012 09:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121124090511.htmNew insights into virus proteome: Unknown proteins of the herpesvirus discoveredhttp://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmScientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmDrug resistance biomarker could improve cancer treatmenthttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmGenome packaging: Key to breast cancer developementhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmShort DNA strands in genome may be key to understanding human cognition and diseaseshttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmBiomarking time: Methylome modifications offer new measure of our 'biological' agehttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmKidney tumors have a mind of their ownhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmMechanism to repair clumped proteins explainedhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmNew test for tuberculosis could improve treatment, prevent deaths in Southern Africahttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htm'Obese but happy gene' challenges the common perception of link between depression and obesityhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Researchers have discovered new genetic evidence about why some people are happier than others. The scientists have uncovered evidence that the gene FTO -- the major genetic contributor to obesity -- is associated with an eight per cent reduction in the risk of depression. In other words, it's not just an obesity gene but a "happy gene" as well.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmFruit fly studies guide investigators to molecular mechanism frequently misregulated in human cancershttp://www.sciencedaily.com/releases/2012/11/121119132056.htm Changes in how DNA interacts with histones ?- the proteins that package DNA ?- regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed.Mon, 19 Nov 2012 13:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121119132056.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmNew factor of genetic susceptibility to Alzheimer's diseasehttp://www.sciencedaily.com/releases/2012/11/121119104944.htm A large-scale international study has just discovered a gene for susceptibility to a rare disease providing evidence of the heterogeneous aetiology of Alzheimer's disease.Mon, 19 Nov 2012 10:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121119104944.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmDNA packaging discovery reveals principles by which CRC mutations may cause cancerhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmHepatitis C treatment's side effects can now be studied in the labhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmReconsidering cancer's bad guyhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmGene distinguishes early birds from night owls and helps predict time of deathhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmClues to cause of kids' brain tumorshttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmArthritis study reveals why gender bias is all in the geneshttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmClass of RNA molecules protects germ cells from damagehttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmQuick test speeds search for Alzheimer's drugs: Compound restores motor function and longevity to fruit flieshttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmProtein-making machinery can switch gears with a small structural change process; Implications for immunity and cancer therapyhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmPlant derivative, tanshinones, protects against sepsis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmStructure of enzyme topoisomerase II alpha unravelled providing basis for more accurate design of chemotherapeutic drugshttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmNewly discovered enzyme important in the spreading of cancerhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmGenetics point to serious pregnancy complication, pre-eclampsiahttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmMolecular mechanisms underlying stem cell reprogramming decodedhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmSurprising genetic link between kidney defects and neurodevelopmental disorders in kidshttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmEven moderate drinking in pregnancy can affect a child's IQhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmGene nearly triples risk of Alzheimer's, international research team findshttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmDiscovery could lead to faster diagnosis for some chronic fatigue syndrome caseshttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmResearch breakthrough could halt melanoma metastasis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmPig genomes provide massive amount of genomic data for human healthhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmRare parasitic fungi could have anti-flammatory benefitshttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmCancer therapy: Nanokey opens tumors to attackhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmHigh sperm DNA damage a leading cause of 'unexplained infertility', research findshttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmA risk gene for cannabis psychosishttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmBacterial DNA sequence used to map an infection outbreakhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmGenetic variation may modify associations between low vitamin D levels and adverse health outcomeshttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmNew type of bacterial protection found within cells: Novel immune system response to infections discoveredhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmGlutamate neurotransmission system may be involved with depression riskhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmTargeting downstream proteins in cancer-causing pathway shows promise in cell, animal modelhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htmEven low-level radioactivity is damaging, scientists concludehttp://www.sciencedaily.com/releases/2012/11/121113134224.htm Even the very lowest levels of radiation are harmful to life, scientists have concluded, reporting the results of a wide-ranging analysis of 46 peer-reviewed studies published over the past 40 years. Variation in low-level, natural background radiation was found to have small, but highly statistically significant, negative effects on DNA as well as several measures of health.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134224.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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